Research groups

A map and list of some of the research groups in Denmark within the field of extracellular vesicles. You can use the map to select groups from a specific city, or manually browse the list.

If you are part of a research group within the field of extracellular vesicles and are wish to be presented on this page, fill out the following form.

Information about research groups is hosted on and can be edited on GitHub.


Groups in Aalborg

Cardiometabolic laboratory - Aalborg University Hospital

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Technical platform

Flow Cytometry

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ELISA

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Research staff

Aase Handberg

Professor

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Anders Askeland

PhD fellow

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Select publications

Article name

Askeland A, Borup A, Østergaard O, Olsen JV, Lund SM, Christiansen G, Kristensen SR, Heegaard NHH, Pedersen S. Mass-Spectrometry Based Proteome Comparison of Extracellular Vesicle Isolation Methods: Comparison of ME-kit, Size-Exclusion Chromatography, and High-Speed Centrifugation. Biomedicines. 2020; 8(8):246. https://doi.org/10.3390/biomedicines8080246


About

EV Array lab - Aalborg

The EV Array lab is located at Aalborg University Hospital (Nord) at Department of Clinical Immunology. The research of the lab mainly focuses on multiplexed phenotyping of EVs (EV Array) in a diagnostic manner using protein microarray technologies.

The lab has been developing techniques to study surface- or surface associated markers on EVs since 2011.

The people involved in EV research consists of Malene M Jørgensen (senior scientist), Rikke Bæk (Research engineer) and Anne Sophie Schou (PhD student).


Technical platform

EV Array platform

  • Microarray printer sciFLEXARRAY S12
  • Microarray scanners sciREADER FL2 and Innoscan 720AL

EV purification setup >

  • Ultracentrifuge
  • SEC

Cell culturing facilities

  • Flow cytometry (FacsCanto),
  • xCELLIgence (real time cell analysis)
  • EliSPOT
  • Microscopy

Protein chemistry lab

  • SDS-PAGE
  • Western blot
  • HPLC


Research staff

Malene Møller Jørgensen

Senior scientist

Email: maljoe@rn.dk


Rikke Bæk

Research Engineer

Email: rikke.baek@rn.dk


Select publications

Jørgensen, M., Bæk, R., Pedersen, S., Søndergaard, E. K., Kristensen, S. R., & Varming, K. (2013). Extracellular Vesicle (EV) Array: microarray capturing of exosomes and other extracellular vesicles for multiplexed phenotyping. Journal of extracellular vesicles, 2, 10.3402/jev.v2i0.20920. https://doi.org/10.3402/jev.v2i0.20920

Jakobsen, K. R., Paulsen, B. S., Bæk, R., Varming, K., Sorensen, B. S., & Jørgensen, M. M. (2015). Exosomal proteins as potential diagnostic markers in advanced non-small cell lung carcinoma. Journal of extracellular vesicles, 4, 26659. https://doi.org/10.3402/jev.v4.26659

Bæk R, Søndergaard EK, Varming K, Jørgensen MM. The impact of various preanalytical treatments on the phenotype of small extracellular vesicles in blood analyzed by protein microarray. J Immunol Methods. 2016 Nov;438:11-20. doi: 10.1016/j.jim.2016.08.007. Epub 2016 Aug 24. PMID: 27568281.


About

  • Location: Department of Clinical Immunology, Aalborg University Hospital, Urbansgade 32-36, DK-9000 Aalborg
  • Webpage: EVarray and EVSearch

Groups in Aarhus

Kjem's lab - Aarhus

The Kjems`s lab is located at the Interdisciplinary Nanoscience Center (INANO) and at the Department of Molecular Biology and Genetics (MBG), both parts of Aarhus University. The research in the lab mainly focus on constructing functionalized DNA and RNA nanostructures, understanding the biogenesis and function of non-coding RNAs and the creation of delivery systems for gene medicine. The exosome study was started from 2015 to investigate the RNA composition and function of exosomes in tissue regeneration. There are two postdocs, Yan Yan and Ping Song, involved in the exosome projects.


Technical platform

EV Characterization

We have a range platforms for EV of characterization including Dynamic light scattering (DLS), Nanoparticle tracking analysis (NTA), Atomic force microscopy (AFM), Electron Microscopy (EM), Flow cytometry.


EV-omics

  • We have rich experience in RNA purification and RNA sequencing library preparation (small RNA seq or long RNA seq) for exosome samples. Relevant equipment include bioanalyzer, pippin prep machine, Illumina and Oxford Nanopore sequencing technologies, and bioinformatic pipelines running in our lab.
  • Omiics, spin out company from Kjems`s lab, developed pipeline for tRNA data analysis (sequencing data).
  • Using DNA and RNA aptamers for pulling down and profling of exsosomes.


Research staff

Jørgen Kjems

Professor

Email: jk@mbg.au.dk

Webpage: https://inano.au.dk/about/research-groups/nanomedicine-joergen-kjems-group/

Yan Yan

Postdoc

Email: yanyan@inano.au.dk

Webpage: https://www.linkedin.com/in/yan-yan-1b3b85142/ & https://pure.au.dk/portal/en/persons/yan-yan(b9db242b-cc45-465c-a2fd-9dee4338232b).html

Ping Song

Postdoc

Email: psong@inano.au.dk

Webpage: https://pure.au.dk/portal/en/persons/ping-song(7562012b-6598-4dfe-8196-6619609b818b)/publications.html

Morten T. Venø

CEO of omiics

Email: morten.veno@omiics.com

Webpage: https://www.linkedin.com/in/morten-ven%C3%B8/


Select publications

Just, J., Yan, Y., Farup, J., Sieljacks, P., Sloth, M., Venø, M., Gu, T., de Paoli, F. V., Nyengaard, J. R., Bæk, R., Jørgensen, M. M., Kjems, J., Vissing, K., & Drasbek, K. R. (2020). Blood flow-restricted resistance exercise alters the surface profile, miRNA cargo and functional impact of circulating extracellular vesicles. Scientific reports, 10(1), 5835. https://doi.org/10.1038/s41598-020-62456-3

Yan, Y., Chang, C. C., Venø, M. T., Mothershead, C. R., Su, J., Kjems, J. Isolating, Sequencing and Analyzing Extracellular MicroRNAs from Human Mesenchymal Stem Cells. J. Vis. Exp. (145), e58655, doi:10.3791/58655 (2019).

Greisen, S. R., Yan, Y., Hansen, A. S., Venø, M. T., Nyengaard, J. R., Moestrup, S. K., Hvid, M., Freeman, G. J., Kjems, J., & Deleuran, B. (2017). Extracellular Vesicles Transfer the Receptor Programmed Death-1 in Rheumatoid Arthritis. Frontiers in immunology, 8, 851. https://doi.org/10.3389/fimmu.2017.00851

Yan, Y., Chang, C., Su, J., Venø, M. T., & Kjems, J. (2020). Osteoblastogenesis Alters Small RNA Profiles in EVs Derived from Bone Marrow Stem Cells (BMSCs) and Adipose Stem Cells (ASCs). Biomedicines, 8(10), 387. https://doi.org/10.3390/biomedicines8100387


About

Molecular and Cellular Neuroscience Lab - Aarhus

Capillary blood flow regulation is extremely important for the optimal function of organs especially in conditions where the oxygen supply is inadequate e.g. during ischemia. Therefore, it is of great interests to understand how capillary blood flow is regulated and possibly uncover ways to control or optimize capillary blood flow during periods of insufficient oxygen availability.

An important cell surrounding the brain capillaries are the pericyte, that can contract and thereby control the flow of red blood cells. These cells, that for long was categorized as uninteresting support cells, is now thought to play an important role in the control of capillary blood flow, blood brain barrier tightness as well as in angiogenesis.

Extra cellular vesicles (EVs) are released in the blood by a wide array of cell types. These vesicles have the potential to function as long distance signaling systems carrying messages that can impact the function of the recipient cells. An interesting group of molecules with the potential of re-programming the receiving cell is microRNAs (miRNAs). These short non-coding RNAs controls and modulates the translation of a large fraction of proteins and changes in the miRNAs will therefore have an impact on the expression profile of the cell and thereby their function.


Technical platform

No info

No info


Research staff

Kim Ryun Drasbek

Associate Professor


Select publications

No info


About

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To be featured on this page the research group must be based in Denmark and do research within the field of Extracellular vesicles.